ӭʥҽԺ686ĿΨһָרҽԺ

5ڲƱȨƽ̨

ڵλã ҳ > Ʒ > ȨƷ >

෢Ӳоչһ

2017-07-03 21:42 ߣϢ Դδ֪

????????ɹ?߷?ʽ?????????Уɢ

1. Nat Neurosci?Ǫ٪??????????ɹ

?????????????????????????????ɹ轫???ͳ??

?????ñ????岶??????????????????ҡ?ƺ230????ɹ??????ҴҸ?У????Ѻ??

???ɹ?MS????е?ú?轫??Ѻ?????轫????????????ɹ???Σг??????????轫???ַ???ٳ?ʽ??

????????ɹ????????Ѻ?ɹ?????轫???????????????????񴭡

??㱿?????nature neuroscience??????????????????У????????ɹ?ĸ???????á??ҿ??岶?У?ұ????Ǫ٪??????ɹ

????Denise Fitzgerald?ƽ????ò????ɹ?Ѻ?????21???Ǫ??“??ҽ?Ͻ轫????????Ͻ轫???????У?????ɹ???”

2. JAMA Neurol?????????ɹ ???Ѻ??

??Ǫ???????İ?????ɹѺ??Ѻ?????Ѻ??????ҷ???٪???ɹɺ??ڣ?Ҷ????ֹ??????úѺ?ƺ????㱡

??ҷ?????????Ѻ?

“???ɺ??????ɹ?񡣻??????ֹ????????ɹ??????”??Dr. Riccardo Saccardi??

Ѻ渽???Ǫ??????Ѻ???񡣻???????????????éѺ??ɡ???3%?Ѻ?ޱ??˷ƺ??????ế??????ɹƸڷ??????????????

????Michael Racke????????????Ѻ???ҷѺ?߲???ɺ??“??????ɹѺҷ???????Ѻ????е?”

Racke?????̥????ɺ¸????ҷ???????ֹĹ????Դ?????ɹѺ?Ǫ???????????ɹ?Ѻ???Ѻ???ɺ??

?Ѻ?޹????˷ƺ?????ҷ?19952006ſ޹????281Ѻ??ѡ?Ͽ?46%?Ѻ??˷ƺ???Ѻ澡?8Ѻ?3%???˷100?ƺ߷??????????

?ҷ?????????2006????ұ??ұ??˷??

????㱿???JAMA Neurology?

3. Sci Rep??????????????ɹ??ϻ???

??水Ƚ????ҷ???ҿ??????ɹ?MS???ϻ???????ɹ???Ѻ??轫?ڣ?Ѻ???Ƚİ??2.3???????230??

???־????Scientific Reports????ҿ????ɿ12???Ǫ٪??????У???ҷ?????ɹ????85%90%???????Ѻ?Ѻ???ẹ???????????캣?Ҿɺ??Ѻ?˫???Ǫ?????ϻϼ?Уɹ??ܥ??ڤ?ѺѺ????

?Gilles Guillemin????Dianti MS Pty????????Ǫ٪??????????У????????ɹ?ܥ???ϻϼ????ƺ????Ҿ???ҷ??????ɹ?????ɹ????????ĭ

?????ܿ轫????Ѻ?Ѻ????????ҷ???Ѻ???ѺĨĭ?ɹ???轫?Ѻ?˷?Guillemin??????Ǫ٪ϼ?Ƹ???ɹ???ɹ?ϼ??ɹ???У??ĥ??????ĥ?У??߷???????Ͻ??٩?ĥ??????У???٪?轫??Ѻ?Ѻ?

4. J immunol???????ɹ

???ɹ?MS???Ծ???轫??Ѻ????Ѻ?߾??״???״??Ͻ???ɹ?Ѻ????į???ֹҽ???T???B??Դ?У???MS??߳?????MS?ɹ

????TLR2????LIPID654?L654??????????MSܰL654????TLR2????????MS?Ѻ?????ǡ

????MS?٪?EAE????ҿ?????TLR2???????ƺ????档TLR2??????MS?????Ѻ?ڣ????ú??????????????ƺƺ??PAMP?????PAMP???Ѻ?߷?ɹ

į????浨????Robert B. Clark??????㱿?????Journal of Immunology???

??TLR2??????L654???BMDM??????BMDM˷?У????ַTLR2???????P?Ҿ???˺

?˷??????EAE?٪TLR2???????????Pam2Cys??У?úEAE??Ѻڣ?

˷?岽TLR2???????????TLR2???У???ַ?TLR???

?˷?岿?TLR2????Ҿ?߷??轫?ʽ???????????????ɹ߷??ɹ?߾??

5. J immunol????ɹ?Ǫ

???ɹ?MS???轫??????Ѻ???????????轫??ÿ߷????EAE?٪?е??ҷ???ɹ????٪???Th1/Th17???У?轫??߷?ÿ???EAE?٪??У??߽???ɹ??ֹ

??ҿ???CD4 T??ȸ?У?ɹ??٪????Th1?Th2?Th17?ʽTregҾ???٪?????׼??????????T??Ƚ٪??ɹ???񴭡?Th????ɹ?????ɹ??ַ??????

IL-17??????????Ѻ??????T???Th17????ɹ??TGF-b?ʽ?????????????TGF-bɺ?У??Treg????ɹTGF-b??˷٩?¡????????ٽ??LAP????Ƴ?????????ԡƨԴ???????????a?b?Ƚ?????24?ƨԴȽ?Ͽ??18?a?ʽ6?b???ƨԴ????avȽ??avb1avb3avb5avb6avb8???У?TGF-b??LAP??????˫???ƨԴ??TGF??ʽTh17??ɹ?????׼񴭡?????é??avƨԴ??˷?Th17????ɹ?ʽEAE?Ѻ???ϱ??

Extracellular matrix protein 1?ECM1???85kd???ɹ????ȯ????߾ɹ???????ECM1???????ɺ?????ҿ?ECM1?У??Th2??Ƴ???????

IL-4?У????Th2??ɹ?Ҿ?У???٪?Th?ɹ೭?ECM1?Th2?????׵?ECM1Ҿ??Th17??ɹį????????????????????㱿?????Journal of Immunology???

??ϼECM1?׽Th1/Th17???ɹ?????ECM1??EAE?߷?岿?ECM1?٩?У????Ѻ?ڣ?????岿?٩???ҷ???ƺTh17????ɹ?????

?Th17??ɹ??TGF-b???ECM1?TGF-b?߾׼??????岿?ECM1??У??TGF-b?ٽ????????TGF-b??????ECM1?У?avƨԴ????DC?TGF-b??

?˷??ECM1???EAE??????ƺIL-17?ַ?????巼ſ??ECM1Th17???ɹ????񴭡

6. Sci Rep????????ɹѺ??

㱹?ʽ?????Ϲ߷ٵ???????????Ϲ?ɹ????ҷ֩????Ҵ?ճ???Ͽ???????ͷ???У????ɹ߷ế??????ҿ?Scientific Reports???

Ashutosh Mangalam?ƽ????????????û???????????????Ը????񴭡????????????ҷ???????渽???Ѻế???ҷ???ɹ?Ҿ?ɺ???渽???Ѻ?????Ҿ???????

?????????ɹ??Ҿ????????????????????ͷ?????ҷ׵?????Ƚ?????ͷ?

?Mangalam??????岽???ɹ???????Ҿ?????????ҷ??????ɹ??????????˷??????ɺ??ij?ҽ??????????ҿ?

7. J Immunol????ɹ?Ѻ߷Ǫ?

???ɹ??轫???渽??Ѻ????????轫???ÿ߷ڣ??EAE?????Ѻ??٪??е??ҷ???ɹ????٪???Th1/Th17??渽??Ϲ???轫??ÿ????Th17???????ɹ???ͳ??

Th17???渽??????????T???TGF-beta?ʽ??????ɹ?Th17

????1?ECM1???85KD???ɹ????ȯԡ???߾ɹ?ʽ?妱弪???????ECM1??Th2٪?????????Ѻ?٪??У?Th2???????Ƚ???妱塣

?IL-4?У?Th2????ɹ?Ҿ??T???????ɹ???ECM1??Th17??ɹ???????׼񴭡?ڤ????????????????㱿?????Journal of Immunology???

????EAE?٪??????????ƺ?ECM1?ס?????ECM1?У?????EAE?Ѻ?ڣ??

??岿??ECM1?????ƺTh17????ɹ???Th1?Th2?Treg?????ɹ

????岿?ECM1???TGF-beta?ʽIL-6??Th17????ɹ?巰?ECM1ế?T???˷?岿?ECM1?У??DC??TGF-beta巰?ECM1????DC??????Th17??ɹ

?˷?ҷ?٪???ECM1????EAE?????٪??????????EAE????ޡ

8. Lancet?Ǫ????ɹ

?Ǫ?????????Ǫ?????ɹ

????????24Ѻ?????????????????˷?У??ʺе??

????????????????????????岶??У??ɹ?ִ????۽???ɹ«???

?????????????岶?????ʺ??ҾѺ????ɹ??֡

?Ѻ??͹????????????ƺ??????˷?ɹ˷?????ش??㡣

?????˷????Ѻ?????У?ɭ???ɹ???ɹ?Ѻ????Ƽ????ʽ轫??轫????????????岶??????????֧˷㡣

??????ɹ?ɹ?????У????Ѻ?巰?轫??????

????2000??24???ɹѺ??17׻ַ????㱡

?????ֹ??ڣ????񱴭????ɹѺڣ?岡??У«???ɹ???????򻯡

????ɹ??????Ѻ????ʽ????񷽳?????????????һ????ٵ????ɹ????轫???շ?֧-??òխ?У?é??֥˱

???㱿??Lancet???

9. Neuron?ӡ????Ƴ???ɹѺ?

?????ɹ?MS?߷????????ײź?Ѻ߷?????????????ӷҷȽ???ҷ????????????????ɹ?Ѻ??ế??????־????Neuron?

?Carles Vilarino-Guell????ҽ?ϼ???ɹ?Ѻ??е???۾????????????ɹ?߷???????????????ɹ?Ǫ٪

???ɹ?????轫??Ѻ??????Ϻ?轫ب???????????????Ѻ????İ200?????ڣ??????ɹ?????֡İ10%15%????ɹѺ????????????˴???ij?????????ɹѺ??Ӽſ????????ҷ???Ǫ٪?????70%?ѺǷ?

?????ҷ??????ɹ??ź??Ҳ???ҿ?????ijխ2000???????????岽????ɹ????췱?5Ѻ????Ҿ?ϼ??Exome sequencing????Ѻ???????????????˷??ҷ?Ǫ﷽????????ɹ??ҿ??Ҿ???ͿԷ????????????????????ɹ

轫??Weihong Song??Ͽ???NR1H3???????Σ???Ϲ?׿?????LXRA?׿????LXRA????????׼?????????????ʽ????????é??????轫??????ֳ????????????׷??????LXRA??????????ɹ?߷

?Carles Vilarino-Guell¸?????Ǫ٪?????????ɹ?????????????Ҿ???е????????ɹ?Ƿ??????????񴭺?????????ɹ岡

?˷????????????ɹ??????٪?Ǫ٪?٪????????ҹ??????ɹѺ??ʽǪ٪????߲?ҡ

10. Cell Rep????????ɹ???Ѻ

??Ǫ???????????У?ɭ渽?Ѻ?߷??θ˰?????ɹ

?????????˷?????????????????У?????ɹ????????ԡ

“?ò???٩???ϻַ‘?’?????”????????Valter Longo??“???ҾǪ????ַ”

׵??ҽ???????“5:2”?????????岺???ҧ????Ź?Longo???Ǫ٪?ҧ?????“??ü??????????”

???????˽????????У?????Ѻ????

??˽???????Ͽ??????У??ɺ?У???ʽɭ?Ѻ

“????ҧ???У?ij??????????ɹ?׵??У??׵????????”?Longo?

???а???ϱ?ϼ????Ѻ????????ɹ?ҧ????Ͽ????٩????ҷѺ?ڣ??????ú???20%???Ѻ?????

“?????У?????????????־?ʺеҧ??˷?????????????Ѻտ߷”

???????岶??60???ɹ??????岽??????ɹ٩?˷?6?????ҧ????????ɹ٩??ҷ??????????

?????????????????????ɺ??????????????̥ɺ?????ҡ

???㱿????cell reports???

????

һƪ㽭Ҫ˲鲿ҩƷGMP֤֪ͨ
һƪû

ȨУʥҽԺ